We are developing and applying innovative screening approaches that will allow researchers to scan large numbers of chemicals and predict which ones are likely to increase breast cancer risk.

Publications and Presentations

Borrel, A., Rudel, R. 2022. Cheminformatics analysis of chemicals that increase estrogen and progesterone synthesis for a breast cancer hazard assessmentScientific Reports. https://doi.org/10.1038/s41598-022-24889-w


Kay J.E., B. Cardona, R.A. Rudel, L.N. Vandenberg, A.M. Soto, S. Christiansen, L.S. Birnbaum, S.E. Fenton. 2022. Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities. Current Environmental Health Reports.  doi.org/10.1007/s40572-022-00376-2.


Rudel, R.A., B. Cardona, A. Borrel, J.E. Kay. 2022. Response to “Comment on ‘Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors’”. Environmental Health Perspectives. https://doi.org/10.1289/EHP11400

Response to Letter

Cardona, B. and R.A. Rudel. 2021. Application of an in vitro assay to identify chemicals that increase estradiol and progesterone synthesis and are potential breast cancer risk factorsEnvironmental Health Perspectives. doi.org/10.1289/EHP8608


Bessonneau, V., and R.A. Rudel. 2020. Mapping the Human Exposome to Uncover the Causes of Breast Cancer. International Journal of Environmental Research and Public Health. 17(1): 189. doi.org/10.3390/ijerph17010189


Grashow, R.G., V.Y. De La Rosa, S.M. Watford, J.M. Ackerman, R.A. Rudel. 2018. BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening. Computational Toxicology. 5:16-24. doi.org/10.1016/j.comtox.2017.11.003.


Rudel, R., Kripke M.L., and Yaswen, P. Predicting Toxicity: Silent Spring Institute's High-throughput Screens for Chemicals Related to Breast Cancer. Collaborative on Health and the Environment. November 12, 2015.

slides and recording

Pan, S., C. Yuan, A. Tagmount, R.A. Rudel, J.M. Ackerman, P. Yaswen, C.D. Vulpe, D.C. Leitman. 2015. Parabens and Human Epidermal Growth Factor Receptor Ligands Cross-Talk in Breast Cancer Cells. Environmental Health Perspectives, 124(5):563-569. doi:10.1289/ehp.1409200


Schwarzman M.R., J.M. Ackerman, S.H. Dairkee, S.E. Fenton, D. Johnson, K.M. Navarro, G. Osborne, R.A. Rudel, G.M. Solomon, L. Zeise, S. Janssen. 2015. Screening for chemical contributions to breast cancer risk:  A case study for chemical safety evaluation. Environmental Health Perspectives, 123(12):1255-1264. doi:10.1289/ehp.1408337